The GSA Journals, GENETICS and G3: Genes|Genomes|Genetics, are proud to present our annual Spotlight booklets for research published in 2019. Each Spotlight is a showcase of the excellent research and scholarship published over the course of the year, along with a selection of striking images submitted by our authors.

Browse the 2019 GENETICS Spotlight.

Browse the 2019 G3 Spotlight.

The GSA Journals, GENETICS and G3: Genes|Genomes|Genetics, are proud to present our annual Spotlight booklets for research published in 2018. Each Spotlight is a showcase of the excellent research and scholarship published over the course of the year, along with a selection of striking images submitted by our authors.

Browse the 2018 GENETICS Spotlight.

Browse the 2018 G3 Spotlight.

The GSA Journals, GENETICS and G3: Genes|Genomes|Genetics, are proud to present our annual Spotlight booklets for research published in 2017. Each Spotlight is a showcase of the excellent research and scholarship published over the course of the year, along with a selection of striking images submitted by our authors.

Browse the 2017 GENETICS Spotlight.

Browse the 2017 G3 Spotlight.

The GSA Journals, GENETICS and G3: Genes|Genomes|Genetics, are proud to present our annual Spotlight booklets for research published in 2016. Each Spotlight is a showcase of the excellent research and scholarship published over the course of the year, along with a selection of striking images submitted by our authors.

Browse the 2016 GENETICS Spotlight.

Browse the 2016 G3 Spotlight.

GENETICS SPOTLIGHT CITATIONS

2016 EDITORS’ CHOICE AWARD: MOLECULAR GENETICS

Degradation of the Mitotic Cyclin Clb3 Is not Required for Mitotic Exit but Is Necessary for G1 Cyclin Control of the Succeeding Cell Cycle

Kresti Pecani and Frederick R. Cross

Genetics December 2016 204:1479–1494

2016 EDITORS’ CHOICE AWARD: POPULATION GENETICS

The Genetic Cost of Neanderthal Introgression

Kelley Harris and Rasmus Nielsen

Genetics June 2016 203: 881-891

2016 EDITORS’ CHOICE AWARD: QUANTITATIVE GENETICS

Evolution of Schooling Behavior in Threespine Sticklebacks Is Shaped by the Eda Gene

Anna K. Greenwood, Margaret G. Mills, Abigail R. Wark, Sophie L. Archambeault, and  Catherine L. Peichel

Genetics June 2016 203: 677–681

CELLULAR GENETICS

Maternal MEMI Promotes Female Meiosis II in Response to Fertilization in Caenorhabditis elegans

Maryam Ataeian, Justus Tegha-Dunghu, Donna G. Curtis, Ellen M. E. Sykes, Ashkan Nozohourmehrabad, Megha Bajaj, Karen Cheung, and Martin Srayko

Genetics December 2016 204: 1461–1477

Commentary: Parental Control Begins at the Beginning

Diana Chu

Genetics December 2016 204: 1377–1378

DEVELOPMENTAL & BEHAVIORAL GENETICS

Hedgehog Signaling Strength Is Orchestrated by the mir-310 Cluster of MicroRNAs in Response to Diet

Ibrahim Ömer Çiçek, Samir Karaca, Marko Brankatschk, Suzanne Eaton, Henning Urlaub, and Halyna R. Shcherbata

Genetics March 2016 202:1167–1183

GENE EXPRESSION

Multitasking of the piRNA Silencing Machinery: Targeting Transposable Elements and Foreign Genes in the Bdelloid Rotifer Adineta vaga

Fernando Rodriguez and Irina R. Arkhipova

Genetics May 2016 203:255–268

GENETICS OF COMPLEX TRAITS

Genetical Genomics of Behavior: A Novel Chicken Genomic Model for Anxiety Behavior

Martin Johnsson, Michael J. Williams, Per Jensen, and Dominic Wright

Genetics January 2016 202: 327–340

GENOME & SYSTEMS BIOLOGY

Genome-Wide Structural Variation Detection by Genome Mapping on Nanochannel Arrays

Angel C. Y. Mak, Yvonne Y. Y. Lai, Ernest T. Lam, Tsz-Piu Kwok, Alden K. Y. Leung, Annie Poon, Yulia Mostovoy, Alex R. Hastie, William Stedman, Thomas Anantharaman, Warren Andrews, Xiang Zhou, Andy W. C. Pang, Heng Dai, Catherine Chu, Chin Lin, Jacob J. K. Wu, Catherine M. L. Li, Jing-Woei Li, Aldrin K. Y. Yim, Saki Chan, Justin Sibert, Željko Džakula, Han Cao, Siu-Ming Yiu, Ting-Fung Chan, Kevin Y. Yip, Ming Xiao, and Pui-Yan Kwok

Genetics January 2016 202: 351–362

GENOME INTEGRITY & TRANSMISSION

A Delicate Balance Between Repair and Replication Factors Regulates Recombination Between Divergent DNA Sequences in Saccharomyces cerevisiae

Ujani Chakraborty, Carolyn M. George, Amy M. Lyndaker, and Eric Alani

Genetics February 2016 202: 525–540

METHODS, TECHNOLOGY, & RESOURCES

Rapid Short-Read Sequencing and Aneuploidy Detection Using MinION Nanopore Technology

Shan Wei and Zev Williams

Genetics January 2016 202: 37–44

PERSPECTIVES

Hubby and Lewontin on Protein Variation in Natural Populations: When Molecular Genetics Came to the Rescue of Population Genetics

Brian Charlesworth, Deborah Charlesworth, Jerry A. Coyne, and Charles H. Langley

Genetics August 2016 203: 1497–1503

POPULATION & EVOLUTIONARY GENETICS

Natural Selection and Genetic Diversity in the Butterfly Heliconius melpomene

Simon H. Martin, Markus Möst, William J. Palmer, Camilo Salazar, W. Owen McMillan, Francis M. Jiggins, and Chris D. Jiggins

Genetics May 2016 203: 525–541

Effects of Linked Selective Sweeps on Demographic Inference and Model Selection

Daniel R. Schrider, Alexander G. Shanku, and Andrew D. Kern

Genetics November 2016 204: 1207–1223

http://www.genetics.org/content/204/3/1207

STATISTICAL GENETICS & GENOMICS

Local Joint Testing Improves Power and Identifies Hidden Heritability in Association Studies

Brielin C. Brown, Alkes L. Price, Nikolaos A. Patsopoulos, and Noah Zaitlen

Genetics July 2016 203: 1105–1116

ON THE COVER

The Evolutionary Origin and Genetic Makeup of Domestic Horses

Pablo Librado, Antoine Fages, Charleen Gaunitz, Michela Leonardi, Stefanie Wagner, Naveed Khan, Kristian Hanghøj, Saleh A. Alquraishi, Ahmed H. Alfarhan, Khaled A. Al-Rasheid, Clio Der Sarkissian, Mikkel Schubert, and Ludovic Orlando

Genetics October 2016 204: 423-424

IMAGES

A Bibliometric History of the Journal GENETICS

Natalie Telis, Benjamin V. Lehmann, Marcus W. Feldman, and Jonathan K. Pritchard

Genetics December 2016 204: 1337–1342

Commonalities in Development of Pure Breeds and Population Isolates Revealed in the Genome of the Sardinian Fonni’s Dog

Dayna L. Dreger, Brian W. Davis, Raffaella Cocco, Sara Sechi, Alessandro Di Cerbo, Heidi G. Parker, Michele Polli, Stefano P. Marelli, Paola Crepaldi, and Elaine A. Ostrander

Genetics October 2016 204: 737-755

G3 SPOTLIGHT CITATIONS

GENOME REPORTS

Whole Genome Sequence of Two Wild-Derived Mus musculus domesticus Inbred Strains, LEWES/EiJ and ZALENDE/EiJ, with Different Diploid Numbers

Andrew P. Morgan, John P. Didion, Anthony G. Doran, James M. Holt, Leonard McMillan, Thomas M. Keane, and Fernando Pardo-Manuel de Villena

G3: Genes|Genomes|Genetics December 2016 6:4211–4216

MUTANT SCREEN REPORT

A Forward Genetic Screen for Molecules Involved in Pheromone-Induced Dauer Formation in Caenorhabditis elegans

Scott J. Neal, JiSoo Park, Danielle DiTirro, Jason Yoon, Mayumi Shibuya, Woochan Choi, Frank C. Schroeder, Rebecca A. Butcher, Kyuhyung Kim, and Piali Sengupta

G3: Genes|Genomes|Genetics May 2016 6:1475–1487

INVESTIGATIONS

Dynamics of Dark-Fly Genome Under Environmental Selections

Minako Izutsu, Atsushi Toyoda, Asao Fujiyama, Kiyokazu Agata, and Naoyuki Fuse

G3: Genes|Genomes|Genetics February 2016 6:365-376

Combinatorial Cis-regulation in Saccharomyces Species

Aaron T. Spivak and Gary D. Stormo

G3: Genes|Genomes|Genetics March 2016 6: 653–667

Preparing for Winter: The Transcriptomic Response Associated with Different Day Lengths in Drosophila montana

Darren J. Parker, Michael G. Ritchie, and Maaria Kankare

G3: Genes|Genomes|Genetics May 2016 6:1373–1381

Transcriptome Analysis Reveals that Vitamin A Metabolism in the Liver Affects Feed Efficiency in Pigs

Yunxia Zhao, Ye Hou, Fei Liu, An Liu, Lu Jing, Changzhi Zhao, Yu Luan, Yuanxin Miao, Shuhong Zhao, and Xinyun Li

G3: Genes|Genomes|Genetics November 2016 6:3615–3624

The Mouse Universal Genotyping Array: From Substrains to Subspecies

Andrew P. Morgan, Chen-Ping Fu, Chia-Yu Kao, Catherine E. Welsh, John P. Didion, Liran Yadgary, Leeanna Hyacinth, Martin T. Ferris, Timothy A. Bell, Darla R. Miller, Paola Giusti-Rodriguez, Randal J. Nonneman, Kevin D. Cook, Jason K. Whitmire, Lisa E. Gralinski, Mark Keller, Alan D. Attie, Gary A. Churchill, Petko Petkov, Patrick F. Sullivan, Jennifer R. Brennan, Leonard McMillan, and Fernando Pardo-Manuel de Villena

G3: Genes|Genomes|Genetics February 2016 6:263–279

Seizure Suppression by High Temperature via cAMP Modulation in Drosophila

Arunesh Saras and Mark A. Tanouye

G3: Genes|Genetics|Genomies October 2016 6:3381-3387

Novel Heterotypic Rox Sites for Combinatorial Dre Recombination Strategies

Katherine Chuang, Eileen Nguyen, Yuri Sergeev, and Tudor C. Badea

G3: Genes|Genomes|Genetics March 2016 6:559-571

Fine-Scale Crossover Rate Variation on the Caenorhabditis elegans X Chromosome

Max R. Bernstein and Matthew V. Rockman

G3: Genes|Genomes|Genetics June 2016 6: 61767–1776

Effects of DNA Methylation and Chromatin State on Rates of Molecular Evolution in Insects

Karl M. Glastad, Michael A. D. Goodisman, Soojin V. Yi, and Brendan G. Hunt

G3: Genes|Genomes|Genetics February 2016 6:357–363

The Effects of Both Recent and Long-Term Selection and Genetic Drift Are Readily Evident in North American Barley Breeding Populations

Ana M. Poets, Mohsen Mohammadi, Kiran Seth, Hongyun Wang, Thomas J. Y. Kono, Zhou Fang, Gary J. Muehlbauer, Kevin P. Smith, and Peter L. Morrell

G3: Genes|Genomes|Genetics March 2016 6:609-622

Canopy Temperature and Vegetation Indices from High-Throughput Phenotyping Improve Accuracy of Pedigree and Genomic Selection for Grain Yield in Wheat

Jessica Rutkoski, Jesse Poland, Suchismita Mondal, Enrique Autrique, Lorena González Pérez, José Crossa, Matthew Reynolds, and Ravi Singh

G3: Genes|Genomes|Genetics September 2016 6:2799–2808

A Combination of CRISPR/Cas9 and Standardized RNAi as a Versatile Platform for the Characterization of Gene Function

Sebastian Wissel, Anja Kieser, Tetsuo Yasugi, Peter Duchek, Elisabeth Roitinger, Joseph Gokcezade, Victoria Steinmann, Ulrike Gaul, Karl Mechtler, Klaus Förstemann, Jürgen A. Knoblich, and Ralph A. Neumüller

G3: Genes|Genomes|Genetics August 2016 6:2467–2478

Genomic Access to Monarch Migration Using TALEN and CRISPR/Cas9-Mediated Targeted Mutagenesis

Matthew J. Markert, Ying Zhang, Metewo S. Enuameh, Steven M. Reppert, Scot A. Wolfe, and Christine Merlin

G3: Genes|Genomes|Genetics April 2016 6:905–915

Whole Genome Comparison Reveals High Levels of Inbreeding and Strain Redundancy Across the Spectrum of Commercial Wine Strains of Saccharomyces cerevisiae

Anthony R. Borneman, Angus H. Forgan, Radka Kolouchova, James A. Fraser, and Simon A. Schmidt

G3: Genes|Genomes|Genetics April 2016 6:957–971

rDNA Copy Number Variants Are Frequent Passenger Mutations in Saccharomyces cerevisiae Deletion Collections and de Novo Transformants

Elizabeth X. Kwan, Xiaobin S. Wang, Haley M. Amemiya, Bonita J. Brewer, and M. K. Raghuraman

G3: Genes|Genomes|Genetics September 2016 6: 2829–2838

ON THE COVER

A Pedigree-Based Map of Recombination in the Domestic Dog Genome

Christopher L. Campbell, Claude Bhérer, Bernice E. Morrow, Adam R. Boyko and Adam Auton

G3: Genes|Genomes|Genetics 6: 3517–3524

IMAGES

Functional Genetic Screen to Identify Interneurons Governing Behaviorally Distinct Aspects of Drosophila Larval Motor Programs

Matt Q. Clark, Stephanie J. McCumsey, Sereno Lopez-Darwin, Ellie S. Heckscher and Chris Q. Doe

G3: Genes|Genomes|Genetics 6: 2023–2031

Estimating Trait Heritability in Highly Fecund Species

Sarah W. Davies, Samuel V. Scarpino, Thanapat Pongwarin, James Scott and Mikhail V. Mat

G3: Genes|Genomes|Genetics 5: 2639–2645

Sequential Turnovers of Sex Chromosomes in African Clawed Frogs (Xenopus) Suggest Some Genomic Regions Are Good at Sex Determination

G3: Genes|Genomes|Genetics 6: 3625-3633

The GSA Journals, GENETICS and G3: Genes|Genomes|Genetics, are proud to present our annual Spotlight booklets for research published in 2015. Each Spotlight is a showcase of the excellent research and scholarship published over the course of the year, along with a selection of striking images submitted by our authors.

Browse the 2015 GENETICS Spotlight.

Browse the 2015 G3 Spotlight.

GENETICS SPOTLIGHT CITATIONS

CENTENNIAL AWARD: MOLECULAR GENETICS

Allelic Imbalance Is a Prevalent and Tissue-Specific Feature of the Mouse Transcriptome

Stefan F. Pinter, David Colognori, Brian J. Beliveau, Ruslan I. Sadreyev, Bernhard Payer, Eda Yildirim, Chao-ting Wu, Jeannie T. Lee

Genetics June, 2015 vol. 200:537-549

CENTENNIAL AWARD: QUANTITATIVE GENETICS

The Nature of Genetic Variation for Complex Traits Revealed by GWAS and Regional Heritability Mapping Analyses

Armando Caballero, Albert Tenesa, Peter D. Keightley

Genetics December, 2015 201:1601-1613

CENTENNIAL AWARD: POPULATION & EVOLUTIONARY GENETICS

Adaptation, Clonal Interference, and Frequency-Dependent Interactions in a Long-Term Evolution Experiment with Escherichia coli

Rohan Maddamsetti, Richard E. Lenski, Jeffrey E. Barrick

Genetics June, 2015 200:619-631

DEVELOPMENTAL & BEHAVIORAL GENETICS

A Novel Paradigm for Nonassociative Long-Term Memory in Drosophila: Predator-Induced Changes in Oviposition Behavior

Balint Z. Kacsoh, Julianna Bozler, Sassan Hodge, Mani Ramaswami, Giovanni Bosco

GENETICS April 2015 199:1143-1157

GENETICS OF COMPLEX TRAITS

Dominance Genetic Variance for Traits Under Directional Selection in Drosophila serrata

Jacqueline L. Sztepanacz and Mark W. Blows

Genetics May 2015 200:371-384

GENE EXPRESSION

Paramutation in Drosophila Requires Both Nuclear and Cytoplasmic Actors of the piRNA Pathway and Induces Cis-spreading of piRNA Production

Catherine Hermant, Antoine Boivin, Laure Teysset, Valérie Delmarre, Amna Asif-Laidin, Marius van den Beek, Christophe Antoniewski, Stéphane Ronsseray

Genetics December 2015 201:1381-1396

The Chromatin and Transcriptional Landscape of Native Saccharomyces cerevisiae Telomeres and Subtelomeric Domains

Aisha Ellahi, Deborah M. Thurtle, Jasper Rine

Genetics June 2015 200:505-521

GENOME & SYSTEMS BIOLOGY

Complementation of Yeast Genes with Human Genes as an Experimental Platform for Functional Testing of Human Genetic Variants

Akil Hamza, Erik Tammpere, Megan Kofoed, Christelle Keong, Jennifer Chiang, Guri Giaever, Corey Nislow, Philip Hieter

Genetics November 2015 201:1263-1274

GENOME INTEGRITY

Alternative Transposition Generates New Chimeric Genes and Segmental Duplications at the Maize p1 Locus

Dafang Wang, Chuanhe Yu, Tao Zuo, Jianbo Zhang, David F. Weber, Thomas Peterson

Genetics November 2015 201:925-935

PERSPECTIVES

What Do You Mean, “Epigenetic”?

Carrie Deans and Keith A. Maggert

Genetics April 2015 199:887-896

POPULATION & EVOLUTIONARY GENETICS

The Evolutionarily Stable Distribution of Fitness Effects

Daniel P. Rice, Benjamin H. Good, Michael M. Desai

Genetics May 2015 200:321-329

Allele Sharing and Evidence for Sexuality in a Mitochondrial Clade of Bdelloid Rotifers

Ana Signorovitch, Jae Hur, Eugene Gladyshev, Matthew Meselson

Genetics June 2015 200:581-590

STATISTICAL GENETICS & GENOMICS

Efficient Multiple-Trait Association and Estimation of Genetic Correlation Using the Matrix-Variate Linear Mixed Model

Nicholas A. Furlotte, Eleazar Eskin

Genetics May 2015 200:59-68

REVIEWS

Genetic Diversity and Societally Important Disparities

Noah A. Rosenberg, Jonathan T. L. Kang

Genetics September 2015 201:1-12

METHODS, TECHNOLOGY, & RESOURCES

Rapid and Precise Engineering of the Caenorhabditis elegans Genome with Lethal Mutation Co-Conversion and Inactivation of NHEJ Repair

Jordan D. Ward

Genetics February 1, 2015 vol. 199  no. 2 363-377

Dramatic Enhancement of Genome Editing by CRISPR/Cas9 Through Improved Guide RNA Design

Behnom Farboud, Barbara J. Meyer

Genetics April 1, 2015 vol. 199  no. 4 959-971

High Efficiency, Homology-Directed Genome Editing in Caenorhabditis elegans Using CRISPR-Cas9 Ribonucleoprotein Complexes

Alexandre Paix, Andrew Folkmann,  Dominique Rasoloson, Geraldine Seydoux

Genetics September 1, 2015 vol. 201  no. 1 47-54

Streamlined Genome Engineering with a Self-Excising Drug Selection Cassette

Daniel J. Dickinson, Ariel M. Pani, Jennifer K. Heppert, Christopher D. Higgins, Bob Goldstein

Genetics August 1, 2015 vol. 200  no. 4 1035-1049

Efficient Genome Editing in Caenorhabditis elegans with a Toolkit of Dual-Marker Selection Cassettes

Adam D. Norris, Hyun-Min Kim, Mónica P. Colaiácovo, John A. Calarco

Genetics October 1, 2015 vol. 201  no. 2 449-458

Targeted Chromosomal Translocations and Essential Gene Knockout Using CRISPR/Cas9 Technology in Caenorhabditis elegans

Xiangyang Chen, Mu Li, Xuezhu Feng, Shouhong Guang

Genetics December 1, 2015 vol. 201  no. 4 1295-1306
 

ON THE COVER

The Functional Basis of Wing Patterning in Heliconius Butterflies: The Molecules Behind Mimicry

Marcus R. Kronforst, Riccardo Papa

Genetics May 1, 2015 200:1-19

G3 SPOTLIGHT CITATIONS

MUTANT SCREEN REPORTS

A Genetic Screen for Saccharomyces cerevisiae Mutants That Fail to Enter Quiescence

Lihong Li, Shawna Miles, and Linda L. Breeden

G3: Genes|Genomes|Genetics August 2015 5:1783-1795

INVESTIGATIONS

Systematic Evaluation of Drosophila CRISPR Tools Reveals Safe and Robust Alternatives to Autonomous Gene Drives in Basic Research

Fillip Port, Nadine Muschalik, and Simon L. Bullock

G3: Genes|Genomes|Genetics  July 2015 5:1493-1502

Global Diversity Lines–A Five-Continent Reference Panel of Sequenced Drosophila melanogaster Strains

Jennifer K. Grenier, J. Roman Arguello, Margarida Cardoso Moreira, Srikanth Gottipati, Jaaved Mohammed, Sean R. Hackett, Rachel Boughton, Anthony J. Greenberg, and Andrew G. Clark

G3: Genes|Genomes|Genetics  April 2015 5:593-603

A Genomic Selection Index Applied to Simulated and Real Data

Jesus Ceron-Rojas, José Crossa, Vivi N. Arief, Kaye Basford, Jessica Rutkoski, Diego Jarquín, Gregorio Alvarado, Yoseph Beyene, Kassa Semagn, and Ian DeLacy

G3: Genes|Genomes|Genetics October 2015 5:2155-2164

Fingerprinting Soybean Germplasm and Its Utility in Genomic Research

Qijian Song, David L. Hyten, Gaofeng Jia, Charles V. Quigley, Edward W. Fickus, Randall L. Nelson, and Perry B. Cregan

G3: Genes|Genomes|Genetics October 2015 5:1999-2006

High-Resolution Linkage Map and Chromosome-Scale Genome Assembly for Cassava (Manihot esculenta Crantz) from 10 Populations

International Cassava Genetic Map Consortium (ICGMC)

G3: Genes|Genomes|Genetics January 2015 5:133-144

Identification of New Players in Cell Division, DNA Damage Response, and Morphogenesis Through Construction of Schizosaccharomyces pombe Deletion Strains

Jun-Song Chen, Janel R. Beckley, Nathan A. McDonald, Liping Ren, MariaSanta Mangione, Sylvia J. Jang, Zachary C. Elmore, Nicole Rachfall, Anna Feoktistova, Christine M. Jones, Alaina H. Willet, Rodrigo Guillen, Danny A. Bitton, Jürg Bähler, Michael A. Jensen, Nick Rhind, and Kathleen L. Gould

G3: Genes|Genomes|Genetics March 2015 5:361-370

The Nature, Extent, and Consequences of Genetic Variation in the opa Repeats of Notch in Drosophila

Clinton Rice, Danielle Beekman, Liping Liu, and Albert Erives

G3: Genes|Genomes|Genetics November 2015 5:2405-2419

Quantitative Genetics of Migration-Related Traits in Rainbow and Steelhead Trout

Benjamin C. Hecht, Jeffrey J. Hard, Frank P. Thrower, and Krista M. Nichols

G3: Genes|Genomes|Genetics May 2015 5:873-889

Analysis of Circadian Rhythms in the Basal Filamentous Ascomycete Pyronema confluens

Stefanie Traeger and Minou Nowrousian

G3: Genes|Genomes|Genetics October 2015 5:2061-2071

RNAseq Analysis Highlights Specific Transcriptome Signatures of Yeast and Mycelial Growth Phases in the Dutch Elm Disease Fungus Ophiostoma novo-ulmi

Martha Nigg, Jérôme Laroche, Christian R. Landry, and Louis Bernier

G3: Genes|Genomes|Genetics November 2015 5:2487-2495

SMRT Sequencing for Parallel Analysis of Multiple Targets and Accurate SNP Phasing

Xiaoge Guo, Kevin Lehner, Karen O’Connell, Jenny Zhang, Sandeep S. Dave, and Sue Jinks-Robertson

G3: Genes|Genomes|Genetics December 2015 5:2801-2808

Genetic Networks Required to Coordinate Chromosome Replication by DNA Polymerases α, δ, and ε in Saccharomyces cerevisiae

Marion Dubarry, Conor Lawless, A. Peter Banks, Simon Cockell, and David Lydall

G3: Genes|Genomes|Genetics October 2015 5:2187-2197

A Powerful New Quantitative Genetics Platform, Combining Caenorhabditis elegans High-Throughput Fitness Assays with a Large Collection of Recombinant Strains

Erik C. Andersen, Tyler C. Shimko, Jonathan R. Crissman, Rajarshi Ghosh, Joshua S. Bloom, Hannah S. Seidel, Justin P. Gerke, and Leonid Kruglyak

G3: Genes|Genomes|Genetics May 2015 5:911-920

A Multifunctional Mutagenesis System for Analysis of Gene Function in Zebrafish

Helen Ngoc Bao Quach, Shijie Tao, Pavle Vrljicak, Adita Joshi, Hua Ruan, Rashmi Sukumaran, Gaurav K. Varshney, Matthew C. LaFave, The Ds Screen Team, Shawn M. Burgess, Christoph Winkler, Alexander Emelyanov, Sergey Parinov, and Karuna Sampath

G3: Genes|Genomes|Genetics June 2015 5:1283-1299

Whole-Exome Sequencing and Targeted Copy Number Analysis in Primary Ciliary Dyskinesia

Christian R. Marshall, Stephen W. Scherer, Maimoona A. Zariwala, Lynette Lau, Tara A. Paton, Tracy Stockley, Rebekah K. Jobling, Peter N. Ray, Michael R. Knowles, FORGE Canada Consortium, David A. Hall, Sharon D. Dell, and Raymond H. Kim

G3: Genes|Genomes|Genetics August 2015 5:1775-1781

ON THE COVER

A Multipurpose, High-Throughput Single-Nucleotide Polymorphism Chip for the Dengue and Yellow Fever Mosquito, Aedes aegypti

Benjamin R. Evans, Andrea Gloria-Soria, Lin Hou, Carolyn McBride, Mariangela Bonizzoni, Hongyu Zhao, and Jeffrey R. Powell

G3:Genes|Genomes|Genetics May 2015 5:711-718

From animal domestication to human genome variation, from loblolly genomes to lager genomes, from wild zebrafish sex to untangled metagenomes, last year brought plenty of high points for the GSA journals. So gathering a small selection of those high points into the 2014 Spotlight booklets was a challenging, but rewarding task for the editors of GENETICS and G3. Each Spotlight is a showcase of the excellent research and scholarship published over the course of the year, along with a selection of striking images submitted by our authors.

Enjoy the 2014 Spotlights at the linked images below. Full text of the articles featured in Spotlight are also available below. You can also browse the 2013 GENETICS Spotlight and the 2013 G3 Spotlight.

GENETICS Spotlight cover:
In 2014, Zimin et al. and Wegrzyn et al. reported the 23-Gb reference sequence of the loblolly pine, the largest genome sequenced and assembled to date.
Image courtesy of Ron Billings, Texas A&M Forest Service.

G3 Spotlight Cover:
In 1883, Emil Christian Hansen isolated the first pure lager yeast strain, Saccharomyces carlsbergensis. In 2014, Walther et al. assembled the genome of S. carlsbergensis. This artwork shows Hansen, his signature, and Circos presentations of the genome. Image courtesy of Andrea Walther.

GENETICS SPOTLIGHT CITATIONS:

CELLULAR GENETICS

Menzel J., M.E. Malo, C. Chan, M. Prusinkiewicz, T. G. Arnason & T. A. A. Harkness (2014). The Anaphase Promoting Complex Regulates Yeast Lifespan and rDNA Stability by Targeting Fob1 for Degradation, Genetics, 196 (3) 693-709. DOI: 10.1534/genetics.113.158949 http://www.genetics.org/content/196/3/693.full

COMPLEX TRAITS

Li Y., R. Cheng, K. A. Spokas, A. A. Palmer & J. O. Borevitz (2014). Genetic Variation for Life History Sensitivity to Seasonal Warming in Arabidopsis thaliana, Genetics, 196 (2) 569-577. DOI: 10.1534/genetics.113.157628 http://www.genetics.org/content/196/2/569.full

DEVELOPMENTAL & BEHAVIORAL GENETICS

Hoover C.M., S.L. Edwards, S.-c. Yu, M. Kittelmann, J. E. Richmond, S. Eimer, R. M. Yorks & K. G. Miller (2014). A Novel CaM Kinase II Pathway Controls the Location of Neuropeptide Release from Caenorhabditis elegans Motor Neurons, Genetics, 196 (3) 745-765. DOI: 10.1534/genetics.113.158568 http://www.genetics.org/content/196/3/745.full

COMMENTARY

Nurrish S. (2014). Dense Core Vesicle Release: Controlling the Where as Well as the When, Genetics, 196 (3) 601-604. DOI: 10.1534/genetics.113.159905 http://www.genetics.org/content/196/3/601.full

GENE EXPRESSION

Wang G., E. Yang, C. L. Brinkmeyer-Langford & J. J. Cai (2014). Additive, Epistatic, and Environmental Effects Through the Lens of Expression Variability QTL in a Twin Cohort, Genetics, 196 (2) 413-425. DOI: 10.1534/genetics.113.157503 http://www.genetics.org/content/196/2/413.full

GENETICS OF SEX

Wilson C.A., S.K. High, B. M. McCluskey, A. Amores, Y.-l. Yan, T. A. Titus, J. L. Anderson, P. Batzel, M. J. Carvan, M. Schartl & J. H. Postlethwait (2014). Wild Sex in Zebrafish: Loss of the Natural Sex Determinant in Domesticated Strains, Genetics, 198 (3) 1291-1308. DOI: 10.1534/genetics.114.169284 http://www.genetics.org/content/198/3/1291.full

GENOME & SYSTEMS BIOLOGY

Reed L.K., K. Lee, Z. Zhang, L. Rashid, A. Poe, B. Hsieh, N. Deighton, N. Glassbrook, R. Bodmer & G. Gibson (2014). Systems Genomics of Metabolic Phenotypes in Wild-Type Drosophila melanogaster, Genetics, 197 (2) 781-793. DOI: 10.1534/genetics.114.163857 http://www.genetics.org/content/197/2/781.full

GENOME INTEGRITY & TRANSMISSION

Bauerly E., S. E. Hughes, D. R. Vietti, D. E. Miller, W. McDowell & R. S. Hawley (2014). Discovery of Supernumerary B Chromosomes in Drosophila melanogaster, Genetics, 196 (4) 1007-1016. DOI: 10.1534/genetics.113.160556 http://www.genetics.org/content/196/4/1007.full

Vrooman L.A., S.I. Nagaoka, T. J. Hassold & P. A. Hunt (2014). Evidence for Paternal Age-Related Alterations in Meiotic Chromosome Dynamics in the Mouse, Genetics, 196 (2) 385-396. DOI: 10.1534/genetics.113.158782 http://www.genetics.org/content/196/2/385.full

METHODS, TECHNOLOGY, & RESOURCES

Raj A., M. Stephens & J. K. Pritchard (2014). fastSTRUCTURE: Variational Inference of Population Structure in Large SNP Data Sets, Genetics, 197 (2) 573-589. DOI: 10.1534/genetics.114.164350 http://www.genetics.org/content/197/2/573.full

PERSPECTIVES

Wilkins A.S., R.W. Wrangham & W. T. Fitch (2014). The “Domestication Syndrome” in Mammals: A Unified Explanation Based on Neural Crest Cell Behavior and Genetics, Genetics, 197 (3) 795-808. DOI: 10.1534/genetics.114.165423 http://www.genetics.org/content/197/3/795.full

POPULATION & EVOLUTIONARY GENETICS

de Vladar H.P. & N. Barton (2014). Stability and Response of Polygenic Traits to Stabilizing Selection and Mutation, Genetics, 197 (2) 749-767. DOI: 10.1534/genetics.113.159111 http://www.genetics.org/content/197/2/749.full

Frenkel E.M., B.H. Good & M. M. Desai (2014). The Fates of Mutant Lineages and the Distribution of Fitness Effects of Beneficial Mutations in Laboratory Budding Yeast Populations, Genetics, 196 (4) 1217-1226. DOI: 10.1534/genetics.113.160069 http://www.genetics.org/content/196/4/1217.full

PRIMERS

Duina A.A., M.E. Miller & J. B. Keeney (2014). Budding Yeast for Budding Geneticists: A Primer on the Saccharomyces cerevisiae Model System, Genetics, 197 (1) 33-48. DOI: 10.1534/genetics.114.163188 http://www.genetics.org/content/197/1/33.full

STATISTICAL GENETICS & GENOMICS

Hormozdiari F., E. Kostem, E. Y. Kang, B. Pasaniuc & E. Eskin (2014). Identifying Causal Variants at Loci with Multiple Signals of Association, Genetics, 198 (2) 497-508. DOI: 10.1534/genetics.114.167908 http://www.genetics.org/content/198/2/497.full

METHODS, TECHNOLOGY, & RESOURCES: CRISPR

Gratz S.J., F.P. Ukken, C. D. Rubinstein, G. Thiede, L. K. Donohue, A. M. Cummings & K. M. O’Connor-Giles (2014). Highly Specific and Efficient CRISPR/Cas9-Catalyzed Homology-Directed Repair in Drosophila, Genetics, 196 (4) 961-971. DOI: 10.1534/genetics.113.160713 http://www.genetics.org/content/196/4/961.full

Li M., H. Yang, J. Zhao, L. Fang, H. Shi, M. Li, Y. Sun, X. Zhang, D. Jiang, L. Zhou & D. Wang & (2014). Efficient and Heritable Gene Targeting in Tilapia by CRISPR/Cas9, Genetics, 197 (2) 591-599. DOI: 10.1534/genetics.114.163667 http://www.genetics.org/content/197/2/591.full

Kim H., T. Ishidate, K. S. Ghanta, M. Seth, D. Conte, M. Shirayama & C. C. Mello (2014). A Co-CRISPR Strategy for Efficient Genome Editing in Caenorhabditis elegans, Genetics, 197 (4) 1069-1080. DOI: 10.1534/genetics.114.166389 http://www.genetics.org/content/197/4/1069.full

Arribere J.A., R.T. Bell, B. X. H. Fu, K. L. Artiles, P. S. Hartman & A. Z. Fire (2014). Efficient Marker-Free Recovery of Custom Genetic Modifications with CRISPR/Cas9 in Caenorhabditis elegans, Genetics, 198 (3) 837-846. DOI: 10.1534/genetics.114.169730 http://www.genetics.org/content/198/3/837.full

Paix A., Y. Wang, H. E. Smith, C.-Y. S. Lee, D. Calidas, T. Lu, J. Smith, H. Schmidt, M. W. Krause & G. Seydoux (2014). Scalable and Versatile Genome Editing Using Linear DNAs with Microhomology to Cas9 Sites in Caenorhabditis elegans, Genetics, 198 (4) 1347-1356. DOI: 10.1534/genetics.114.170423 http://www.genetics.org/content/198/4/1347.full

SPOTLIGHT IMAGES

Zimin A., K.A. Stevens, M. W. Crepeau, A. Holtz-Morris, M. Koriabine, G. Marcais, D. Puiu, M. Roberts, J. L. Wegrzyn, P. J. de Jong, D. B. Neale, S.L. Salzberg, J.A. Yorke & C.H. Langley (2014). Sequencing and Assembly of the 22-Gb Loblolly Pine Genome, Genetics, 196 (3) 875-890. DOI: 10.1534/genetics.113.159715 http://www.genetics.org/content/196/3/875.full

Wegrzyn J.L., J.D. Liechty, K. A. Stevens, L.-S. Wu, C. A. Loopstra, H. A. Vasquez-Gross, W. M. Dougherty, B. Y. Lin, J. J. Zieve, P. J. Martínez-García, C. Holt, M. Yandell, A.V. Zimin, J.A. Yorke, M.W. Crepeau, D. Puiu, S.L. Salzberg, P.J. de Jong, K. Mockaitis, D. Main, C.H. Langley & D.B. Neale (2014). Unique Features of the Loblolly Pine (Pinus taeda L.) Megagenome Revealed Through Sequence Annotation, Genetics, 196 (3) 891-909. DOI: 10.1534/genetics.113.159996 http://www.genetics.org/content/196/3/891.full

Stronach B., A.L. Lennox & R. A. Garlena (2014). Domain Specificity of MAP3K Family Members, MLK and Tak1, for JNK Signaling in Drosophila, Genetics, 197 (2) 497-513. DOI: 10.1534/genetics.113.160937 http://www.genetics.org/content/197/2/497.full

Wilkening S., G. Lin, E. S. Fritsch, M. M. Tekkedil, S. Anders, R. Kuehn, M. Nguyen, R. S. Aiyar, M. Proctor, N. A. Sakhanenko, D. J. Galas, J. Gagneur, A. Deutschbauer & L.M. Steinmetz (2014). An Evaluation of High-Throughput Approaches to QTL Mapping in Saccharomyces cerevisiae, Genetics, 196 (3) 853-865. DOI: 10.1534/genetics.113.160291 http://www.genetics.org/content/196/3/853.full

Bannister S., O. Antonova, A. Polo, C. Lohs, N. Hallay, A. Valinciute, F. Raible & K. Tessmar-Raible (2014). TALENs Mediate Efficient and Heritable Mutation of Endogenous Genes in the Marine Annelid Platynereis dumerilii, Genetics, 197 (1) 77-89. DOI: 10.1534/genetics.113.161091 http://www.genetics.org/content/197/1/77.full

Zantke J., S. Bannister, V. B. V. Rajan, F. Raible & K. Tessmar-Raible (2014). Genetic and Genomic Tools for the Marine Annelid Platynereis dumerilii, Genetics, 197 (1) 19-31. DOI: 10.1534/genetics.112.148254 http://www.genetics.org/content/197/1/19.full

LaFave M.C., G.K. Varshney, M. Vemulapalli, J. C. Mullikin & S. M. Burgess (2014). A Defined Zebrafish Line for High-Throughput Genetics and Genomics: NHGRI-1, Genetics, 198 (1) 167-170. DOI: 10.1534/genetics.114.166769 http://www.genetics.org/content/198/1/167.full

Brooks S.S., A.L. Wall, C. Golzio, D. W. Reid, A. Kondyles, J. R. Willer, C. Botti, C. V. Nicchitta, N. Katsanis & E. E. Davis (2014). A Novel Ribosomopathy Caused by Dysfunction of RPL10 Disrupts Neurodevelopment and Causes X-Linked Microcephaly in Humans, Genetics, 198 (2) 723-733. DOI: 10.1534/genetics.114.168211 http://www.genetics.org/content/198/2/723.full

G3 SPOTLIGHT CITATIONS: 

INVESTIGATIONS

Burton J.N., I. Liachko, M. J. Dunham & J. Shendure (2014). Species-Level Deconvolution of Metagenome Assemblies with Hi-C-Based Contact Probability Maps, G3, 4 (7) 1339-1346. DOI: 10.1534/g3.114.011825 http://www.g3journal.org/content/4/7/1339.full

Atencio D., C. Barnes, T. M. Duncan, I. M. Willis & S. D. Hanes (2014). The Yeast Ess1 Prolyl Isomerase Controls Swi6 and Whi5 Nuclear Localization, G3, 4 (3) 523-537. DOI: 10.1534/g3.113.008763 http://www.g3journal.org/content/4/3/523.full

Mezmouk S. & J. Ross-Ibarra (2014). The Pattern and Distribution of Deleterious Mutations in Maize, G3, 4 (1) 163-171. DOI: 10.1534/g3.113.008870 http://www.g3journal.org/content/4/1/163.full

Spivakov M., T.O. Auer, R. Peravali, I. Dunham, D. Dolle, A. Fujiyama, A. Toyoda, T. Aizu, Y. Minakuchi, F. Loosli & K. Naruse, E. Birney & J. Wittbrodt (2014). Genomic and Phenotypic Characterization of a Wild Medaka Population: Towards the Establishment of an Isogenic Population Genetic Resource in Fish, G3, 4 (3) 433-445. DOI: 10.1534/g3.113.008722 http://www.g3journal.org/content/4/3/433.full

Glater E.E., M.V. Rockman & C. I. Bargmann (2014). Multigenic Natural Variation Underlies Caenorhabditis elegans Olfactory Preference for the Bacterial Pathogen Serratia marcescens, G3, 4 (2) 265-276. DOI: 10.1534/g3.113.008649 http://www.g3journal.org/content/4/2/265.full

Hahn M.W., S.V. Zhang & L. C. Moyle (2014). Sequencing, Assembling, and Correcting Draft Genomes Using Recombinant Populations, G3, 4 (4) 669-679. DOI: 10.1534/g3.114.010264 http://www.g3journal.org/content/4/4/669.full

Rajagopal N., J. Ernst, P. Ray, J. Wu, M. Zhang, M. Kellis & B. Ren (2014). Distinct and Predictive Histone Lysine Acetylation Patterns at Promoters, Enhancers, and Gene Bodies, G3, 4 (11) 2051-2063. DOI: 10.1534/g3.114.013565 http://www.g3journal.org/content/4/11/2051.full

Engel S.R., F.S. Dietrich, D. G. Fisk, G. Binkley, R. Balakrishnan, M. C. Costanzo, S. S. Dwight, B. C. Hitz, K. Karra, R. S. Nash, S. Weng, E.D. Wong, P. Lloyd, M.S. Skrzypek, S.R. Miyasato, M. Simison & J.M. Cherry (2014). The Reference Genome Sequence of Saccharomyces cerevisiae: Then and Now, G3, 4 (3) 389-398. DOI: 10.1534/g3.113.008995 http://www.g3journal.org/content/4/3/389.full

Rice W.R. (2014). An X-Linked Sex Ratio Distorter in Drosophila simulans That Kills or Incapacitates Both Noncarrier Sperm and Sons, G3, 4 (10) 1837-1848. DOI: 10.1534/g3.114.013292 http://www.g3journal.org/content/4/10/1837.full

Rogers R.L., L. Shao, J. S. Sanjak, P. Andolfatto & K. R. Thornton (2014). Revised Annotations, Sex-Biased Expression, and Lineage-Specific Genes in the Drosophila melanogaster Group, G3, 4 (12) 2345-2351. DOI: 10.1534/g3.114.013532 http://www.g3journal.org/content/4/12/2345.full

Pang A.W.C., J.R. MacDonald, R. K. C. Yuen, V. M. Hayes & S. W. Scherer (2014). Performance of High-Throughput Sequencing for the Discovery of Genetic Variation Across the Complete Size Spectrum, G3, 4 (1) 63-65. DOI: 10.1534/g3.113.008797 http://www.g3journal.org/content/4/1/63.full

Vaughn J.N., R.L. Nelson, Q. Song, P. B. Cregan & Z. Li (2014). The Genetic Architecture of Seed Composition in Soybean Is Refined by Genome-Wide Association Scans Across Multiple Populations, G3, 4 (11) 2283-2294. DOI: 10.1534/g3.114.013433 http://www.g3journal.org/content/4/11/2283.full

Walther A., A. Hesselbart & J. Wendland (2014). Genome Sequence of Saccharomyces carlsbergensis, the World’s First Pure Culture Lager Yeast, G3, 4 (5) 783-793. DOI: 10.1534/g3.113.010090 http://www.g3journal.org/content/4/5/783.full

MUTANT SCREEN REPORT

Hayashi R., S.M. Wainwright, S. J. Liddell, S. M. Pinchin, S. Horswell & D. Ish-Horowicz (2014). A Genetic Screen Based on in Vivo RNA Imaging Reveals Centrosome-Independent Mechanisms for Localizing gurken Transcripts in Drosophila, G3, 4 (4) 749-760. DOI: 10.1534/g3.114.010462 http://www.g3journal.org/content/4/4/749.full

SPOTLIGHT IMAGES

Lehnert E.M., M.E. Mouchka, M. S. Burriesci, N. D. Gallo, J. A. Schwarz & J. R. Pringle (2014). Extensive Differences in Gene Expression Between Symbiotic and Aposymbiotic Cnidarians, G3, 4 (2) 277-295. DOI: 10.1534/g3.113.009084 http://www.g3journal.org/content/4/2/277.full

Jovelin R., J.S. Comstock, A. D. Cutter & P. C. Phillips (2014). A Recent Global Selective Sweep on the age-1 Phosphatidylinositol 3-OH Kinase Regulator of the Insulin-Like Signaling Pathway Within Caenorhabditis remanei, G3, 4 (6) 1123-1133. DOI: 10.1534/g3.114.010629 http://www.g3journal.org/content/4/6/1123.full

Sikkink K.L., R.M. Reynolds, C. M. Ituarte, W. A. Cresko & P. C. Phillips (2014). Rapid Evolution of Phenotypic Plasticity and Shifting Thresholds of Genetic Assimilation in the Nematode Caenorhabditis remanei, G3, 4 (6) 1103-1112. DOI: 10.1534/g3.114.010553 http://www.g3journal.org/content/4/6/1103.full

INVESTIGATIONS: CRISPR

Xue Z., M. Ren, M. Wu, J. Dai, Y. S. Rong & G. Gao (2014). Efficient Gene Knock-out and Knock-in with Transgenic Cas9 in Drosophila, G3, 4 (5) 925-929. DOI: 10.1534/g3.114.010496 http://www.g3journal.org/content/4/5/925.full

Lee J.S., S.-J. Kwak, J. Kim, A.-K. Kim, H. M. Noh, J.-S. Kim & K. Yu (2014). RNA-Guided Genome Editing in Drosophila with the Purified Cas9 Protein, G3, 4 (7) 1291-1295. DOI: 10.1534/g3.114.012179 http://www.g3journal.org/content/4/7/1291.full

Ren X., Z. Yang, D. Mao, Z. Chang, H.-H. Qiao, X. Wang, J. Sun, Q. Hu, Y. Cui, L.-P. Liu, J.-Y. Ji, J. Xu & J.-Q Ni (2014). Performance of the Cas9 Nickase System in Drosophila melanogaster, G3, 4 (10) 1955-1962. DOI: 10.1534/g3.114.013821 http://www.g3journal.org/content/4/10/1955.full

Xue Z., M. Wu, K. Wen, M. Ren, L. Long, X. Zhang & G. Gao (2014). CRISPR/Cas9 Mediates Efficient Conditional Mutagenesis in Drosophila, G3, 4 (11) 2167-2173. DOI: 10.1534/g3.114.014159 http://www.g3journal.org/content/4/11/2167.full

Gokcezade J., G. Sienski & P. Duchek (2014). Efficient CRISPR/Cas9 Plasmids for Rapid and Versatile Genome Editing in Drosophila, G3, 4 (11) 2279-2282. DOI: 10.1534/g3.114.014126 http://www.g3journal.org/content/4/11/2279.full

Upadhyay S.K., J. Kumar, A. Alok & R. Tuli (2014). RNA-Guided Genome Editing for Target Gene Mutations in Wheat, G3, 3 (12) 2233-2238. DOI: 10.1534/g3.113.008847 http://www.g3journal.org/content/3/12/2233.full

Vilain S., R. Vanhauwaert, Maes, N. Schoovaerts, L. Zhou, S. Soukup, R. da Cunha, E. Lauwers, M. Fiers & P. Verstreken (2014). Fast and Efficient Drosophila melanogaster Gene Knock-Ins Using MiMIC Transposons, G3, 4 (12) 2381-2387. DOI: 10.1534/g3.114.014803 http://www.g3journal.org/content/4/12/2381.full

Zhang X., W.H. Koolhaas & F. Schnorrer (2014). A Versatile Two-Step CRISPR- and RMCE-Based Strategy for Efficient Genome Engineering in Drosophila, G3, 4 (12) 2409-2418. DOI: 10.1534/g3.114.013979 http://www.g3journal.org/content/4/12/2409.full

The GSA Journals, GENETICS and G3: Genes|Genomes|Genetics, are proud to present our annual Spotlight booklets for research published in 2013. Each Spotlight is a showcase of the excellent research and scholarship published over the course of the year, along with a selection of striking images submitted by our authors.

Browse the 2013 GENETICS Spotlight.

Browse the 2013 G3 Spotlight.